SLCO1B1
Identifiers
AliasesSLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6, solute carrier organic anion transporter family member 1B1
External IDsOMIM: 604843 HomoloGene: 74575 GeneCards: SLCO1B1
Orthologs
SpeciesHumanMouse
Entrez

10599

n/a

Ensembl

ENSG00000134538

n/a

UniProt

Q9Y6L6

n/a

RefSeq (mRNA)

NM_006446

n/a

RefSeq (protein)

NP_006437

n/a

Location (UCSC)Chr 12: 21.13 – 21.24 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Solute carrier organic anion transporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene.[3][4] Pharmacogenomic research indicates that genetic variations in this gene are associated with response to simvastatin.[5] Clinical guidelines exist that can guide dosing of simvastatin based on SLCO1B1 gene variant using genotyping or whole exome sequencing.[6]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000134538 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Abe T, Kakyo M, Tokui T, Nakagomi R, Nishio T, Nakai D, Nomura H, Unno M, Suzuki M, Naitoh T, Matsuno S, Yawo H (Jul 1999). "Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1". J Biol Chem. 274 (24): 17159–63. doi:10.1074/jbc.274.24.17159. PMID 10358072.
  4. "Entrez Gene: SLCO1B1 solute carrier organic anion transporter family, member 1B1".
  5. Carr DF, O'Meara H, Jorgensen AL, Campbell J, Hobbs M, McCann G, van Staa T, Pirmohamed M (2013). "SLCO1B1 Genetic Variant Associated with Statin-Induced Myopathy: A Proof-of-Concept Study Using the Clinical Practice Research Datalink". Clinical Pharmacology & Therapeutics. 94 (6): 695–701. doi:10.1038/clpt.2013.161. PMC 3831180. PMID 23942138.
  6. Huser V, Cimino JJ (2013). "Providing pharmacogenomics clinical decision support using whole genome sequencing data as input". AMIA Summits on Translational Science Proceedings AMIA Summit on Translational Science. 2013: 81. PMID 24303303.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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