TRAK2
Identifiers
AliasesTRAK2, ALS2CR3, CALS-C, GRIF-1, GRIF1, MILT2, OIP98, trafficking kinesin protein 2
External IDsOMIM: 607334 MGI: 1918077 HomoloGene: 22861 GeneCards: TRAK2
Orthologs
SpeciesHumanMouse
Entrez

66008

70827

Ensembl

ENSG00000115993

ENSMUSG00000026028

UniProt

O60296

n/a

RefSeq (mRNA)

NM_015049

NM_172406

RefSeq (protein)

NP_055864

n/a

Location (UCSC)Chr 2: 201.38 – 201.45 MbChr 1: 58.9 – 58.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Trafficking kinesin-binding protein 2 is a protein that in humans is encoded by the TRAK2 gene.[5][6][7]

Interactions

TRAK2 has been shown to interact with Kir2.1[8] and GABRB2.[9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000115993 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026028 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hadano S, Yanagisawa Y, Skaug J, Fichter K, Nasir J, Martindale D, Koop BF, Scherer SW, Nicholson DW, Rouleau GA, Ikeda J, Hayden MR (Jan 2001). "Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2". Genomics. 71 (2): 200–13. doi:10.1006/geno.2000.6392. PMID 11161814.
  6. Gilbert SL, Zhang L, Forster ML, Anderson JR, Iwase T, Soliven B, Donahue LR, Sweet HO, Bronson RT, Davisson MT, Wollmann RL, Lahn BT (Feb 2006). "Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice". Nature Genetics. 38 (2): 245–50. doi:10.1038/ng1715. PMID 16380713. S2CID 20231963.
  7. "Entrez Gene: TRAK2 trafficking protein, kinesin binding 2".
  8. Grishin A, Li H, Levitan ES, Zaks-Makhina E (Oct 2006). "Identification of gamma-aminobutyric acid receptor-interacting factor 1 (TRAK2) as a trafficking factor for the K+ channel Kir2.1". The Journal of Biological Chemistry. 281 (40): 30104–11. doi:10.1074/jbc.M602439200. PMID 16895905.
  9. Beck M, Brickley K, Wilkinson HL, Sharma S, Smith M, Chazot PL, Pollard S, Stephenson FA (Aug 2002). "Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1". The Journal of Biological Chemistry. 277 (33): 30079–90. doi:10.1074/jbc.M200438200. PMID 12034717.

Further reading


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