TCIM
Identifiers
AliasesTCIM, TC-1, TC1, C8orf4, chromosome 8 open reading frame 4, transcriptional and immune response regulator
External IDsOMIM: 607702 MGI: 1916318 HomoloGene: 10590 GeneCards: TCIM
Orthologs
SpeciesHumanMouse
Entrez

56892

69068

Ensembl

ENSG00000176907

ENSMUSG00000056313

UniProt

Q9NR00

Q9D915

RefSeq (mRNA)

NM_020130

NM_026931

RefSeq (protein)

NP_064515

NP_081207

Location (UCSC)Chr 8: 40.15 – 40.16 MbChr 8: 24.93 – 24.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TCIM is a protein that in humans is encoded by the TCIM gene.[5][6]

Function

This gene encodes a small, monomeric, predominantly unstructured protein (106 amino acids, 12.3 kDa, isoelectric point 9.39).[7] It is a positive regulator of the Wnt / beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000176907 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056313 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chua EL, Young L, Wu WM, Turtle JR, Dong Q (November 2000). "Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer". Genomics. 69 (3): 342–7. doi:10.1006/geno.2000.6348. PMID 11056052.
  6. 1 2 "Entrez Gene: C8orf4 chromosome 8 open reading frame 4".
  7. Kozlowski LP (October 2016). "IPC - Isoelectric Point Calculator". Biology Direct. 11 (1): 55. doi:10.1186/s13062-016-0159-9. PMC 5075173. PMID 27769290.

Further reading

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