SLC30A10
Identifiers
AliasesSLC30A10, HMDPC, ZNT10, ZNT8, ZRC1, ZnT-10, solute carrier family 30 member 10, HMNDYT1
External IDsOMIM: 611146 MGI: 2685058 HomoloGene: 100946 GeneCards: SLC30A10
Orthologs
SpeciesHumanMouse
Entrez

55532

226781

Ensembl

ENSG00000196660

ENSMUSG00000026614

UniProt

Q6XR72

Q3UVU3

RefSeq (mRNA)

NM_001004433
NM_018713
NM_001376929

NM_001033286

RefSeq (protein)

NP_061183
NP_001363858
NP_061183.2

NP_001028458

Location (UCSC)Chr 1: 219.69 – 219.96 MbChr 1: 185.19 – 185.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Solute carrier family 30 member 10 is a protein that in humans is encoded by the SLC30A10 gene. [5]

Function

This gene is highly expressed in the liver and is inducible by manganese. Its protein product appears to be critical in maintaining manganese levels, and has higher specificity for manganese than zinc. Loss of function mutations appear to result in a pleomorphic phenotype, including dystonia and adult-onset parkinsonism. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012].

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000196660 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026614 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Solute carrier family 30 member 10". Retrieved 2017-11-03.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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