SRPRB
Identifiers
AliasesSRPRB, APMCF1, SRP receptor beta subunit, SRP receptor subunit beta, SR-beta
External IDsOMIM: 616883 MGI: 102964 HomoloGene: 6332 GeneCards: SRPRB
Orthologs
SpeciesHumanMouse
Entrez

58477

20818

Ensembl

ENSG00000144867

ENSMUSG00000032553

UniProt

Q9Y5M8

P47758

RefSeq (mRNA)

NM_021203
NM_001379313

NM_009275

RefSeq (protein)

NP_067026
NP_001366242

NP_033301

Location (UCSC)Chr 3: 133.78 – 133.83 MbChr 9: 103.07 – 103.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Signal recognition particle receptor subunit beta is a protein that in humans is encoded by the SRPRB gene.[5][6][7]

The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000144867 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032553 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Miller JD, Tajima S, Lauffer L, Walter P (Mar 1995). "The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane". J Cell Biol. 128 (3): 273–82. doi:10.1083/jcb.128.3.273. PMC 2120348. PMID 7844142.
  6. Legate KR, Falcone D, Andrews DW (Oct 2000). "Nucleotide-dependent binding of the GTPase domain of the signal recognition particle receptor beta-subunit to the alpha-subunit". J Biol Chem. 275 (35): 27439–46. doi:10.1074/jbc.M003215200. PMID 10859309.
  7. 1 2 "Entrez Gene: SRPRB signal recognition particle receptor, B subunit".

Further reading


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