SFRP2
Identifiers
AliasesSFRP2, FRP-2, SARP1, SDF-5, secreted frizzled related protein 2
External IDsOMIM: 604157 MGI: 108078 HomoloGene: 56438 GeneCards: SFRP2
Orthologs
SpeciesHumanMouse
Entrez

6423

20319

Ensembl

ENSG00000145423

ENSMUSG00000027996

UniProt

Q96HF1

P97299

RefSeq (mRNA)

NM_003013

NM_009144

RefSeq (protein)

NP_003004

NP_033170

Location (UCSC)Chr 4: 153.78 – 153.79 MbChr 3: 83.67 – 83.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Secreted frizzled-related protein 2 is a protein that in humans is encoded by the SFRP2 gene.[5][6] This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer.[6]

New cardiomyocytes can be regenerated in the mouse heart via Sfrp2 and this may lead to treatment of heart injury .

Cancer

SFRP2 gene has been detected progressively overexpressed in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.[7] For this reason, this gene is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000145423 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027996 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Melkonyan HS, Chang WC, Shapiro JP, Mahadevappa M, Fitzpatrick PA, Kiefer MC, Tomei LD, Umansky SR (Jan 1998). "SARPs: A family of secreted apoptosis-related proteins". Proc Natl Acad Sci U S A. 94 (25): 13636–41. doi:10.1073/pnas.94.25.13636. PMC 28358. PMID 9391078.
  6. 1 2 "Entrez Gene: SFRP2 secreted frizzled-related protein 2".
  7. 1 2 Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1002/jcp.24808. hdl:11392/2066612. PMID 25205602. S2CID 24986454.

Further reading

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