RRM1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRRM1, R1, RIR1, RR1, ribonucleotide reductase catalytic subunit M1
External IDsOMIM: 180410 MGI: 98180 HomoloGene: 806 GeneCards: RRM1
Orthologs
SpeciesHumanMouse
Entrez

6240

20133

Ensembl

ENSG00000167325

ENSMUSG00000030978

UniProt

P23921

P07742

RefSeq (mRNA)

NM_001033
NM_001318064
NM_001318065
NM_001330193

NM_009103

RefSeq (protein)

NP_001024
NP_001304993
NP_001304994
NP_001317122

NP_033129

Location (UCSC)Chr 11: 4.09 – 4.14 MbChr 7: 102.09 – 102.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ribonucleoside-diphosphate reductase large subunit is an enzyme that in humans is encoded by the RRM1 gene.[5][6]

This gene encodes one of two non-identical subunits which constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. This gene is oriented in a head-to-tail configuration with the stromal interaction molecule 1 gene (STIM1), with the 3' end of STIM1 situated 1.6 kb from the 5' end of this gene.[6]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

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FluoropyrimidineActivity_WP1601
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FluoropyrimidineActivity_WP1601
|alt=Fluorouracil (5-FU) Activity edit]]
Fluorouracil (5-FU) Activity edit
  1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000167325 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030978 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Parker NJ, Begley CG, Fox RM (Nov 1995). "Human gene for the large subunit of ribonucleotide reductase (RRM1): functional analysis of the promoter". Genomics. 27 (2): 280–5. doi:10.1006/geno.1995.1043. PMID 7557993.
  6. 1 2 "Entrez Gene: RRM1 ribonucleotide reductase M1 polypeptide".

Further reading


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