RPN1
Identifiers
AliasesRPN1, OST1, RBPH1, ribophorin I
External IDsOMIM: 180470 MGI: 98084 HomoloGene: 2213 GeneCards: RPN1
Orthologs
SpeciesHumanMouse
Entrez

6184

103963

Ensembl

ENSG00000163902

ENSMUSG00000030062

UniProt

P04843

Q91YQ5

RefSeq (mRNA)

NM_002950

NM_133933

RefSeq (protein)

NP_002941

NP_598694

Location (UCSC)Chr 3: 128.62 – 128.68 MbChr 6: 88.06 – 88.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dolichyl-diphosphooligosaccharide—protein glycosyltransferase subunit 1 is an enzyme that in humans is encoded by the RPN1 gene.[5]

This gene encodes a type I integral ribophorin membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein should not be confused with RPN1 of yeast, Drosophila, and C. elegans, which forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. The human version of this proteasome subunit is PSMD2.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000163902 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030062 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: RPN1 ribophorin I".

Further reading


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