PPP1R3A
Identifiers
AliasesPPP1R3A, GM, PP1G, PPP1R3, protein phosphatase 1 regulatory subunit 3A
External IDsOMIM: 600917 MGI: 2153588 HomoloGene: 48124 GeneCards: PPP1R3A
Orthologs
SpeciesHumanMouse
Entrez

5506

140491

Ensembl

ENSG00000154415

ENSMUSG00000042717

UniProt

Q16821

Q99MR9

RefSeq (mRNA)

NM_002711

NM_080464

RefSeq (protein)

NP_002702

NP_536712

Location (UCSC)Chr 7: 113.88 – 114.08 MbChr 6: 14.71 – 14.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein phosphatase 1 regulatory subunit 3A is an enzyme that in humans is encoded by the PPP1R3A gene.[5][6]

The glycogen-associated form of protein phosphatase-1 (PP1) derived from skeletal muscle is a heterodimer composed of a 37-kD catalytic subunit (MIM 176875) and a 124-kD targeting and regulatory subunit, referred to as PP1G by Hansen et al. (1995).

PP1G binds to muscle glycogen with high affinity, thereby enhancing dephosphorylation of glycogen-bound substrates for PP1 such as glycogen synthase (e.g., MIM 138570) and glycogen phosphorylase kinase (e.g., MIM 306000). Phosphorylation at ser46 of the PP1G subunit in response to insulin increases PP1 activity, while phosphorylation at ser65 in response to adrenaline causes dissociation of the catalytic subunit from the G subunit and inhibits glycogen synthesis.

Because of these functions, PP1G was postulated to be involved in noninsulin-dependent diabetes mellitus (NIDDM; MIM 125853) and obesity.[supplied by OMIM][6] }}

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000154415 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042717 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chen YH, Hansen L, Chen MX, Bjorbaek C, Vestergaard H, Hansen T, Cohen PT, Pedersen O (Nov 1994). "Sequence of the human glycogen-associated regulatory subunit of type 1 protein phosphatase and analysis of its coding region and mRNA level in muscle from patients with NIDDM". Diabetes. 43 (10): 1234–41. doi:10.2337/diabetes.43.10.1234. PMID 7926294.
  6. 1 2 "Entrez Gene: PPP1R3A protein phosphatase 1, regulatory (inhibitor) subunit 3A (glycogen and sarcoplasmic reticulum binding subunit, skeletal muscle)".

Further reading


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