PPM1A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPPM1A, PP2C-ALPHA, PP2CA, PP2Calpha, protein phosphatase, Mg2+/Mn2+ dependent 1A
External IDsOMIM: 606108 MGI: 99878 HomoloGene: 56428 GeneCards: PPM1A
Orthologs
SpeciesHumanMouse
Entrez

5494

19042

Ensembl

ENSG00000100614

ENSMUSG00000021096

UniProt

P35813

P49443

RefSeq (mRNA)

NM_021003
NM_177951
NM_177952

NM_008910

RefSeq (protein)

NP_066283
NP_808820
NP_808821

NP_032936

Location (UCSC)Chr 14: 60.25 – 60.3 MbChr 12: 72.76 – 72.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein phosphatase 1A is an enzyme that in humans is encoded by the PPM1A gene.[5][6]

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding two distinct isoforms have been described.[6]

Interactions

PPM1A has been shown to interact with Metabotropic glutamate receptor 3.[7] In 2006, Dr. Feng found that PPM1A can terminate TGF-beta signaling by inactivating Smad3 via dephosphorylation. Smad3 is an essential component of the TGF-beta signalling pathway.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000100614 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021096 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Mann DJ, Campbell DG, McGowan CH, Cohen PT (February 1992). "Mammalian protein serine/threonine phosphatase 2C: cDNA cloning and comparative analysis of amino acid sequences". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1130 (1): 100–4. doi:10.1016/0167-4781(92)90471-b. PMID 1311954.
  6. 1 2 "Entrez Gene: PPM1A protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform".
  7. Flajolet M, Rakhilin S, Wang H, Starkova N, Nuangchamnong N, Nairn AC, Greengard P (December 2003). "Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3". Proceedings of the National Academy of Sciences of the United States of America. 100 (26): 16006–11. Bibcode:2003PNAS..10016006F. doi:10.1073/pnas.2136600100. PMC 307683. PMID 14663150.

Further reading

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