PLXNB2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPLXNB2, MM1, Nbla00445, PLEXB2, dJ402G11.3, plexin B2
External IDsOMIM: 604293 MGI: 2154239 HomoloGene: 66630 GeneCards: PLXNB2
Orthologs
SpeciesHumanMouse
Entrez

23654

140570

Ensembl

ENSG00000196576

ENSMUSG00000036606

UniProt

O15031

B2RXS4

RefSeq (mRNA)

NM_012401

NM_001159521
NM_001284506
NM_138749

RefSeq (protein)

NP_001152993
NP_001271435
NP_620088

Location (UCSC)Chr 22: 50.27 – 50.31 MbChr 15: 89.04 – 89.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Plexin-B2 is a protein that in humans is encoded by the PLXNB2 gene.[5][6][7]

Function

Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002)).[supplied by OMIM][7]

Interactions

PLXNB2 has been shown to interact with ARHGEF11.[6][8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000196576 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036606 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM (Oct 1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995.
  6. 1 2 Perrot V, Vazquez-Prado J, Gutkind JS (Nov 2002). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". J Biol Chem. 277 (45): 43115–20. doi:10.1074/jbc.M206005200. PMID 12183458.
  7. 1 2 "Entrez Gene: PLXNB2 plexin B2".
  8. Swiercz JM, Kuner R, Behrens J, Offermanns S (Jul 2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology". Neuron. 35 (1): 51–63. doi:10.1016/S0896-6273(02)00750-X. PMID 12123608.

Further reading


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