PITPNM1
Identifiers
AliasesPITPNM1, DRES9, NIR2, PITPNM, RDGB, RDGB1, RDGBA, RDGBA1, Rd9, phosphatidylinositol transfer protein membrane associated 1
External IDsOMIM: 608794 MGI: 1197524 HomoloGene: 3608 GeneCards: PITPNM1
Orthologs
SpeciesHumanMouse
Entrez

9600

18739

Ensembl

ENSG00000110697

ENSMUSG00000024851

UniProt

O00562

O35954

RefSeq (mRNA)

NM_001130848
NM_004910

NM_001136078
NM_008851

RefSeq (protein)

NP_001124320
NP_004901

NP_032877

Location (UCSC)Chr 11: 67.49 – 67.51 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Membrane-associated phosphatidylinositol transfer protein 1 is a protein that in humans is encoded by the PITPNM1 gene.[4][5]

Function

PITPNM1 belongs to a family of proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein.[supplied by OMIM][5]

It was found that aggressive metastasized cancer cells produced more of the PITPNC1 protein. In contrast, tumor cells that had not spread had lower expression of PITPNC1. Studies reveal that PITPNC1 promotes malignant secretion by binding Golgi-resident PI4P and localizing RAB1B to the Golgi. RAB1B localization to the Golgi allows for the recruitment of GOLPH3 (Golgi phosphoprotein 3), which facilitates Golgi extension and enhanced vesicular release. PITPNC1-mediated vesicular release drives metastasis by increasing the secretion of pro-invasive and pro-angiogenic mediators HTRA1, MMP1, FAM3C, PDGFA, and ADAM10.[6]

Interactions

PITPNM1 has been shown to interact with PTK2B.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000110697 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Rubboli F, Bulfone A, Bogni S, Marchitiello A, Zollo M, Borsani G, Ballabio A, Banfi S (1997). "A mammalian homologue of the Drosophila retinal degeneration B gene: implications for the evolution of phototransduction mechanisms". Genes Funct. 1 (3): 205–13. doi:10.1046/j.1365-4624.1997.00015.x. PMID 9680295.
  5. 1 2 "Entrez Gene: PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1".
  6. Halberg N, Sengelaub CA, Navrazhina K, Molina H, Uryu K, Tavazoie SF (2016). "PITPNC1 Recruits RAB1B to the Golgi Network to Drive Malignant Secretion". Cancer Cell. 29 (3): 339–353. doi:10.1016/j.ccell.2016.02.013. PMC 5300038. PMID 26977884.
  7. Lev S; Hernandez J; Martinez R; Chen A; Plowman G; Schlessinger J (Mar 1999). "Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein". Mol. Cell. Biol. (published March 1999). 19 (3): 2278–88. doi:10.1128/mcb.19.3.2278. ISSN 0270-7306. PMC 84020. PMID 10022914. Wikidata Q22008764.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.