PDE11A
Identifiers
AliasesPDE11A, PPNAD2, phosphodiesterase 11A
External IDsOMIM: 604961 MGI: 3036251 HomoloGene: 56763 GeneCards: PDE11A
Orthologs
SpeciesHumanMouse
Entrez

50940

241489

Ensembl

n/a

ENSMUSG00000075270

UniProt

Q9HCR9

P0C1Q2

RefSeq (mRNA)

NM_016953
NM_001077196
NM_001077197
NM_001077358

NM_001081033

RefSeq (protein)

NP_001070664
NP_001070665
NP_001070826
NP_058649

NP_001074502

Location (UCSC)n/aChr 2: 75.82 – 76.17 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A is an enzyme that in humans is encoded by the PDE11A gene.[4][5]

The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing's disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.[5]

Inhibitors

References

  1. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000075270 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Fawcett L, Baxendale R, Stacey P, McGrouther C, Harrow I, Soderling S, Hetman J, Beavo JA, Phillips SC (Apr 2000). "Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A". Proc Natl Acad Sci U S A. 97 (7): 3702–7. doi:10.1073/pnas.050585197. PMC 16303. PMID 10725373.
  5. 1 2 "Entrez Gene: PDE11A phosphodiesterase 11A".
  6. Ceyhan O, Birsoy K, Hoffman CS (2012). "Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen". Chem. Biol. 19 (1): 155–63. doi:10.1016/j.chembiol.2011.12.010. hdl:2345/2934. PMID 22284362.

Further reading

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