NIN
Identifiers
AliasesNIN, SCKL7, ninein
External IDsOMIM: 608684 MGI: 105108 HomoloGene: 40632 GeneCards: NIN
Orthologs
SpeciesHumanMouse
Entrez

51199

18080

Ensembl

ENSG00000100503

ENSMUSG00000021068

UniProt

Q8N4C6

Q61043

RefSeq (mRNA)

NM_016350
NM_020921
NM_182944
NM_182945
NM_182946

NM_001081453
NM_001286079
NM_001286080
NM_008697

RefSeq (protein)

NP_057434
NP_065972
NP_891989
NP_891991

NP_001074922
NP_001273008
NP_001273009
NP_032723
NP_001390761

Location (UCSC)Chr 14: 50.72 – 50.83 MbChr 12: 70.06 – 70.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ninein is a protein that in humans is encoded by the NIN gene.[5][6][7]

Function

Ninein, together with its paralog Ninein-like protein is one of the proteins important for centrosomal function. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported.[7]

This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000100503 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021068 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hong YR, Chen CH, Chang JH, Wang S, Sy WD, Chou CK, Howng SL (Oct 2000). "Cloning and characterization of a novel human ninein protein that interacts with the glycogen synthase kinase 3beta". Biochim Biophys Acta. 1492 (2–3): 513–6. doi:10.1016/S0167-4781(00)00127-5. PMID 11004522.
  6. Hong YR, Chen CH, Chuo MH, Liou SY, Howng SL (Feb 2001). "Genomic organization and molecular characterization of the human ninein gene". Biochem. Biophys. Res. Commun. 279 (3): 989–95. doi:10.1006/bbrc.2000.4050. PMID 11162463.
  7. 1 2 3 "Entrez Gene: NIN ninein (GSK3B interacting protein)".

Further reading


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