NEIL2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNEIL2, NEH2, NEI2, nei like DNA glycosylase 2
External IDsOMIM: 608933 MGI: 2686058 HomoloGene: 17032 GeneCards: NEIL2
Orthologs
SpeciesHumanMouse
Entrez

252969

382913

Ensembl

ENSG00000154328

ENSMUSG00000035121

UniProt

Q969S2

Q6R2P8

RefSeq (mRNA)

NM_001135746
NM_001135747
NM_001135748
NM_145043

NM_201610

RefSeq (protein)

NP_963904

Location (UCSC)n/aChr 14: 63.42 – 63.43 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Endonuclease VIII-like 2 is an enzyme that in humans is encoded by the NEIL2 gene.[4][5][6]

NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002)[supplied by OMIM][6]

References

  1. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035121 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Hazra TK, Kow YW, Hatahet Z, Imhoff B, Boldogh I, Mokkapati SK, Mitra S, Izumi T (Aug 2002). "Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions". J Biol Chem. 277 (34): 30417–20. doi:10.1074/jbc.C200355200. PMID 12097317.
  5. Das S, Chattopadhyay R, Bhakat KK, Boldogh I, Kohno K, Prasad R, Wilson SH, Hazra TK (Sep 2007). "Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress". J Biol Chem. 282 (39): 28474–84. doi:10.1074/jbc.M704672200. PMC 2679419. PMID 17686777.
  6. 1 2 "Entrez Gene: NEIL2 nei like 2 (E. coli)".

Further reading

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