mir-370
Identifiers
Symbolmir-370
RfamRF00740
miRBase familyMIPF0000167
Other data
RNA typemicroRNA
Domain(s)Eukaryota;
PDB structuresPDBe

In molecular biology mir-370 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. This microRNA, mir-370-3p, has been shown to play a role in heart failure. The upregulation of mir-370-3p in the sinus node leads to downregulation of the pacemaker ion channel, HCN4, and thus downregulation of the corresponding ionic current, which causes sinus bradycardia.[1]

See also

References

  1. Yanni, Joseph; D’Souza, Alicia; Wang, Yanwen; Li, Ning; Hansen, Brian J.; Zakharkin, Stanislav O.; Smith, Matthew; Hayward, Christina; Whitson, Bryan A.; Mohler, Peter J.; Janssen, Paul M. L.; Zeef, Leo; Choudhury, Moinuddin; Zi, Min; Cai, Xue; Logantha, Sunil Jit R. J.; Nakao, Shu; Atkinson, Andrew; Petkova, Maria; Doris, Ursula; Ariyaratnam, Jonathan; Cartwright, Elizabeth J.; Griffiths-Jones, Sam; Hart, George; Fedorov, Vadim V.; Oceandy, Delvac; Dobrzynski, Halina; Boyett, Mark R. (9 July 2020). "Silencing miR-370-3p rescues funny current and sinus node function in heart failure". Scientific Reports. 10 (1): 11279. doi:10.1038/s41598-020-67790-0. PMC 7347645. PMID 32647133.

Further reading


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