MOGAT2
Identifiers
AliasesMOGAT2, DGAT2L5, MGAT2, DGAT2L5., hDC5, monoacylglycerol O-acyltransferase 2
External IDsOMIM: 610270 MGI: 2663253 HomoloGene: 57020 GeneCards: MOGAT2
Orthologs
SpeciesHumanMouse
Entrez

80168

233549

Ensembl

ENSG00000166391

ENSMUSG00000052396

UniProt

Q3SYC2

Q80W94

RefSeq (mRNA)

NM_025098

NM_177448

RefSeq (protein)

NP_079374

NP_803231

Location (UCSC)Chr 11: 75.72 – 75.73 MbChr 7: 98.87 – 98.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

2-Acylglycerol O-acyltransferase 2 also known as acyl-CoA:monoacylglycerol acyltransferase 2 (MGAT2) or Diacylglycerol O-acyltransferase candidate 5 (DC5) is an enzyme that in humans is encoded by the MOGAT2 gene.

MOGAT2 and the related MOGAT3 genes are members of the acylglycerol o-acyltransferase family (DGAT2/MOGAT) and are involved in the synthesis of diacylglycerol (DAG) and triacylglycerol (TAG) from monoacylglycerol (MAG).

MOGAT2 and also MOGAT3 are single copy genes in almost all mammals. However, in ruminants both genes have undergone tandem gene expansion, indicate of evolving functionality. MOGAT2 has more than five tandemly duplicated copies in sheep with the first copy expressed in the duodenum and the last copy expressed in the skin, with no expression of any copy detected in the liver.[5][6][7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000166391 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052396 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Winter A, van Eckeveld M, Bininda-Emonds OR, Habermann FA, Fries R (Feb 2004). "Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals". Cytogenetic and Genome Research. 102 (1–4): 42–7. doi:10.1159/000075723. PMID 14970677. S2CID 25524277.
  6. "Entrez Gene: MOGAT2 monoacylglycerol O-acyltransferase 2".
  7. Jiang Y, Xie M, Chen W, Talbot R, Maddox JF, Faraut T, Wu C, Muzny DM, Li Y, Zhang W, Stanton JA, Brauning R, Barris WC, Hourlier T, Aken BL, Searle SM, Adelson DL, Bian C, Cam GR, Chen Y, Cheng S, DeSilva U, Dixen K, Dong Y, Fan G, Franklin IR, Fu S, Fuentes-Utrilla P, Guan R, Highland MA, Holder ME, Huang G, Ingham AB, Jhangiani SN, Kalra D, Kovar CL, Lee SL, Liu W, Liu X, Lu C, Lv T, Mathew T, McWilliam S, Menzies M, Pan S, Robelin D, Servin B, Townley D, Wang W, Wei B, White SN, Yang X, Ye C, Yue Y, Zeng P, Zhou Q, Hansen JB, Kristiansen K, Gibbs RA, Flicek P, Warkup CC, Jones HE, Oddy VH, Nicholas FW, McEwan JC, Kijas JW, Wang J, Worley KC, Archibald AL, Cockett N, Xu X, Wang W, Dalrymple BP (Jun 2014). "The sheep genome illuminates biology of the rumen and lipid metabolism". Science. 344 (6188): 1168–73. doi:10.1126/science.1252806. PMC 4157056. PMID 24904168.

Further reading


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