MARCKSL1
Identifiers
AliasesMARCKSL1, F52, MACMARCKS, MLP, MLP1, MRP, MARCKS-like 1, MARCKS like 1
External IDsOMIM: 602940 MGI: 97143 HomoloGene: 40748 GeneCards: MARCKSL1
Orthologs
SpeciesHumanMouse
Entrez

65108

17357

Ensembl

ENSG00000175130

ENSMUSG00000047945

UniProt

P49006

P28667

RefSeq (mRNA)

NM_023009

NM_010807

RefSeq (protein)

NP_075385

NP_034937

Location (UCSC)Chr 1: 32.33 – 32.34 MbChr 4: 129.41 – 129.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

MARCKS-related protein is a protein that in humans is encoded by the MARCKSL1 gene.[5][6]

Function

This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. MARCKS play a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein affects the formation of adherens junction. Alternative splicing results in multiple transcript variants.[6]

Interactions

MARCKSL1 has been shown to interact with DCTN2[7] and JNK.[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000175130 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047945 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Stumpo DJ, Eddy RL, Haley LL, Sait S, Shows TB, Lai WS, Young WS, Speer MC, Dehejia A, Polymeropoulos M, Blackshear PJ (August 1998). "Promoter sequence, expression, and fine chromosomal mapping of the human gene (MLP) encoding the MARCKS-like protein: identification of neighboring and linked polymorphic loci for MLP and MACS and use in the evaluation of human neural tube defects". Genomics. 49 (2): 253–64. doi:10.1006/geno.1998.5247. PMID 9598313.
  6. 1 2 "Entrez Gene: MARCKSL1 MARCKS-like 1".
  7. Yue L, Lu S, Garces J, Jin T, Li J (August 2000). "Protein kinase C-regulated dynamitin-macrophage-enriched myristoylated alanine-rice C kinase substrate interaction is involved in macrophage cell spreading". J. Biol. Chem. 275 (31): 23948–56. doi:10.1074/jbc.M001845200. PMID 10827182.
  8. Björkblom B, Padzik A, Mohammad H, Westerlund N, Komulainen E, Hollos P, Parviainen L, Papageorgiou AC, Iljin K, Kallioniemi O, Kallajoki M, Courtney MJ, Mågård M, James P, Coffey ET (September 2012). "c-Jun N-terminal kinase phosphorylation of MARCKSL1 determines actin stability and migration in neurons and in cancer cells". Mol Cell Biol. 32 (17): 3513–26. doi:10.1128/MCB.00713-12. PMC 3421996. PMID 22751924.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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