IL27RA
Identifiers
AliasesIL27RA, CRL1, IL-27RA, IL27R, TCCR, WSX1, zcytor1, Interleukin 27 receptor, alpha subunit, interleukin 27 receptor subunit alpha
External IDsOMIM: 605350 MGI: 1355318 HomoloGene: 3562 GeneCards: IL27RA
Orthologs
SpeciesHumanMouse
Entrez

9466

50931

Ensembl

ENSG00000104998
ENSG00000288185

ENSMUSG00000005465

UniProt

Q6UWB1

O70394

RefSeq (mRNA)

NM_004843

NM_016671

RefSeq (protein)

NP_004834

NP_057880

Location (UCSC)Chr 19: 14.03 – 14.05 MbChr 8: 84.76 – 84.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin 27 receptor, alpha is a subunit of the interleukin-27 receptor. IL27RA is its human gene.[5]

Function

In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein.[5]

Interactions

Interleukin 27 receptor, alpha subunit has been shown to interact with STAT1.[6]

References

  1. 1 2 3 ENSG00000288185 GRCh38: Ensembl release 89: ENSG00000104998, ENSG00000288185 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005465 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: IL27RA interleukin 27 receptor, alpha".
  6. Takeda A, Hamano S, Yamanaka A, Hanada T, Ishibashi T, Mak TW, Yoshimura A, Yoshida H (May 2003). "Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment". J. Immunol. 170 (10): 4886–90. doi:10.4049/jimmunol.170.10.4886. PMID 12734330.

Further reading


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