IFI6
Identifiers
AliasesIFI6, 6-16, FAM14C, G1P3, IFI-6-16, IFI616, interferon alpha inducible protein 6
External IDsOMIM: 147572 HomoloGene: 49720 GeneCards: IFI6
Orthologs
SpeciesHumanMouse
Entrez

2537

n/a

Ensembl

ENSG00000126709

n/a

UniProt

P09912

n/a

RefSeq (mRNA)

NM_022873
NM_002038
NM_022872

n/a

RefSeq (protein)

NP_002029
NP_075010
NP_075011

n/a

Location (UCSC)Chr 1: 27.67 – 27.67 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Interferon alpha-inducible protein 6 is a protein that in humans is encoded by the IFI6 gene.[3]

This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A mini-satellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mammalian splice donor consensus sequence begins near the end of the second exon. Alternatively spliced transcript variants that encode different isoforms by using the two downstream repeat units as splice donor sites have been described.[3]

An antiviral function has been attributed to IFI6 against several members of theFlaviviridae family (DENV, YFV, ZIKV, WNV). IFI6 was able to interfere with the virus replication by preventing the formation of virus-induced membrane structures that represent a replication organelle.[4]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000126709 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. 1 2 "Entrez Gene: IFI6 interferon, alpha-inducible protein 6".
  4. Richardson RB, Ohlson MB, Eitson JL, Kumar A, McDougal MB, Boys IN, et al. (November 2018). "A CRISPR screen identifies IFI6 as an ER-resident interferon effector that blocks flavivirus replication". Nature Microbiology. 3 (11): 1214–1223. doi:10.1038/s41564-018-0244-1. PMC 6202210. PMID 30224801.

Further reading


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