GPSM1
Identifiers
AliasesGPSM1, AGS3, G-protein signaling modulator 1, G protein signaling modulator 1
External IDsOMIM: 609491 MGI: 1915089 HomoloGene: 16987 GeneCards: GPSM1
Orthologs
SpeciesHumanMouse
Entrez

26086

67839

Ensembl

ENSG00000160360

ENSMUSG00000026930

UniProt

Q86YR5

Q6IR34

RefSeq (mRNA)

NM_001145638
NM_001145639
NM_001200003
NM_015597

RefSeq (protein)

NP_001139110
NP_001139111
NP_001186932
NP_056412

Location (UCSC)Chr 9: 136.33 – 136.36 MbChr 2: 26.21 – 26.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

G-protein-signaling modulator 1 is a protein that in humans is encoded by the GPSM1 gene.[5][6][7]

G proteins propagate intracellular signals initiated by G protein-coupled receptors. GPSM1, a receptor-independent activator of G protein signaling, is one of several factors that influence the basal activity of G protein signaling systems (Pizzinat et al., 2001).[supplied by OMIM][7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000160360 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026930 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Pizzinat N, Takesono A, Lanier SM (May 2001). "Identification of a truncated form of the G-protein regulator AGS3 in heart that lacks the tetratricopeptide repeat domains". J Biol Chem. 276 (20): 16601–10. doi:10.1074/jbc.M007573200. PMID 11278352.
  6. Peterson YK, Bernard ML, Ma H, Hazard S III, Graber SG, Lanier SM (Nov 2000). "Stabilization of the GDP-bound conformation of Gialpha by a peptide derived from the G-protein regulatory motif of AGS3". J Biol Chem. 275 (43): 33193–6. doi:10.1074/jbc.C000509200. PMID 10969064.
  7. 1 2 "Entrez Gene: GPSM1 G-protein signalling modulator 1 (AGS3-like, C. elegans)".

Further reading


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