SRSF10
Identifiers
AliasesSRSF10, FUSIP1, FUSIP2, NSSR, PPP1R149, SFRS13, SFRS13A, SRp38, SRrp40, TASR, TASR1, TASR2, serine/arginine-rich splicing factor 10, serine and arginine rich splicing factor 10
External IDsOMIM: 605221 MGI: 1333805 HomoloGene: 134051 GeneCards: SRSF10
Orthologs
SpeciesHumanMouse
Entrez

10772

14105

Ensembl

ENSG00000188529

ENSMUSG00000028676

UniProt

O75494
Q5JRI1

Q9R0U0

RefSeq (mRNA)

NM_001080387
NM_001284195
NM_001284196
NM_010178

RefSeq (protein)

NP_001073856
NP_001271124
NP_001271125
NP_034308

Location (UCSC)Chr 1: 23.96 – 23.98 MbChr 4: 135.58 – 135.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FUS-interacting serine-arginine-rich protein 1 is a protein that in humans is encoded by the SFRS13A gene.[5][6][7]

Function

This gene product is a member of the serine-arginine (SR) family of proteins, which is involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein can influence splice site selection of adenovirus E1A pre-mRNA. It interacts with the oncoprotein TLS and abrogates the influence of TLS on E1A pre-mRNA splicing. Alternative splicing of this gene results in at least two transcript variants encoding different isoforms. In addition, transcript variants utilizing alternative polyA sites exist.[7]

Interactions

FUSIP1 has been shown to interact with FUS.[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000188529 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028676 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Yang L, Embree LJ, Tsai S, Hickstein DD (November 1998). "Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing". J. Biol. Chem. 273 (43): 27761–4. doi:10.1074/jbc.273.43.27761. PMID 9774382.
  6. Clinton JM, Chansky HA, Odell DD, Zielinska-Kwiatkowska A, Hickstein DD, Yang L (March 2002). "Characterization and expression of the human gene encoding two translocation liposarcoma protein-associated serine-arginine (TASR) proteins". Gene. 284 (1–2): 141–7. doi:10.1016/S0378-1119(02)00382-7. PMID 11891055.
  7. 1 2 "Entrez Gene: FUSIP1 FUS interacting protein (serine/arginine-rich) 1".
  8. Yang L, Embree LJ, Hickstein DD (May 2000). "TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteins". Mol. Cell. Biol. 20 (10): 3345–54. doi:10.1128/MCB.20.10.3345-3354.2000. PMC 85627. PMID 10779324.

Further reading


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