FBXL5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFBXL5, FBL4, FBL5, FLR1, F-box and leucine-rich repeat protein 5, F-box and leucine rich repeat protein 5
External IDsOMIM: 605655 MGI: 2152883 HomoloGene: 8129 GeneCards: FBXL5
Orthologs
SpeciesHumanMouse
Entrez

26234

242960

Ensembl

ENSG00000118564

ENSMUSG00000039753

UniProt

Q9UKA1

Q8C2S5

RefSeq (mRNA)

NM_001193534
NM_001193535
NM_012161

NM_001159963
NM_178729

RefSeq (protein)

NP_001180463
NP_001180464
NP_036293

NP_001153435
NP_848844

Location (UCSC)Chr 4: 15.6 – 15.68 MbChr 5: 43.9 – 43.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

F-box/LRR-repeat protein 5 is a protein that in humans is encoded by the FBXL5 gene.[5][6]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternative splicing of this gene generates 2 transcript variants.[6]

FBXL5 is an iron sensor. It promotes IRP2 ubiquitination and then its degradation.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000118564 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039753 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.
  6. 1 2 "Entrez Gene: FBXL5 F-box and leucine-rich repeat protein 5".

Further reading


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