DDOST
Identifiers
AliasesDDOST, AGER1, CDG1R, OKSWcl45, OST, OST48, WBP1, dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit, GATD6
External IDsOMIM: 602202 MGI: 1194508 HomoloGene: 3821 GeneCards: DDOST
Orthologs
SpeciesHumanMouse
Entrez

1650

13200

Ensembl

ENSG00000244038

ENSMUSG00000028757

UniProt

P39656

O54734

RefSeq (mRNA)

NM_005216

NM_007838

RefSeq (protein)

NP_005207

NP_031864

Location (UCSC)Chr 1: 20.65 – 20.66 MbChr 4: 138.03 – 138.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dolichyl-diphosphooligosaccharide—protein glycosyltransferase 48 kDa subunit is an enzyme that in humans is encoded by the DDOST gene.[5][6]

This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000244038 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028757 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Yamagata T, Tsuru T, Momoi MY, Suwa K, Nozaki Y, Mukasa T, Ohashi H, Fukushima Y, Momoi T (Jan 1998). "Genome organization of human 48-kDa oligosaccharyltransferase (DDOST)". Genomics. 45 (3): 535–40. doi:10.1006/geno.1997.4966. PMID 9367678.
  6. 1 2 "Entrez Gene: DDOST dolichyl-diphosphooligosaccharide-protein glycosyltransferase".

Further reading


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