DAZAP2
Identifiers
AliasesDAZAP2, PRTB, DAZ associated protein 2
External IDsOMIM: 607431 MGI: 1344344 HomoloGene: 8038 GeneCards: DAZAP2
Orthologs
SpeciesHumanMouse
Entrez

9802

23994

Ensembl

ENSG00000183283

ENSMUSG00000000346

UniProt

Q15038

Q9DCP9

RefSeq (mRNA)

NM_011873

RefSeq (protein)

NP_036003

Location (UCSC)Chr 12: 51.24 – 51.27 MbChr 15: 100.51 – 100.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DAZ-associated protein 2 is a protein that in humans is encoded by the DAZAP2 gene.[5][6][7]

Function

In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region and is deleted in many azoospermic and severely oligospermic men. It is thought that the Y chromosomal DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL.[7]

Interactions

DAZAP2 has been shown to interact with DAZ1.[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000183283 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000000346 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH (Aug 2000). "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1". Genomics. 65 (3): 266–73. doi:10.1006/geno.2000.6169. PMID 10857750.
  6. Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
  7. 1 2 "Entrez Gene: DAZAP2 DAZ associated protein 2".
  8. Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH (May 2000). "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1". Genomics. 65 (3): 266–73. doi:10.1006/geno.2000.6169. PMID 10857750.

Further reading


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