CYFIP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCYFIP1, P140SRA-1, SHYC, SRA-1, SRA1, cytoplasmic FMR1 interacting protein 1
External IDsOMIM: 606322 MGI: 1338801 HomoloGene: 22628 GeneCards: CYFIP1
Orthologs
SpeciesHumanMouse
Entrez

23191

20430

Ensembl

ENSG00000280618
ENSG00000273749
ENSG00000288461

ENSMUSG00000030447

UniProt

Q7L576

Q7TMB8

RefSeq (mRNA)

NM_001164661
NM_001164662
NM_011370

RefSeq (protein)

NP_001158133
NP_001158134
NP_035500

Location (UCSC)Chr 15: 22.87 – 22.98 MbChr 7: 55.49 – 55.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cytoplasmic FMR1-interacting protein 1 is a protein that in humans is encoded by the CYFIP1 gene.[5][6]


Interactions

CYFIP1 has been shown to interact with FMR1,[5] to the exclusion of FXR1 and FXR2.[5] It also forms part of the WAVE regulatory complex (WRC),[7] and based on the crystal structure of the WRC it is believed CYFIP1 provides the binding site for the complex to Rac1.[8]

References

  1. 1 2 3 ENSG00000273749, ENSG00000288461 GRCh38: Ensembl release 89: ENSG00000280618, ENSG00000273749, ENSG00000288461 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030447 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 3 Schenck A, Bardoni B, Moro A, Bagni C, Mandel JL (Jul 2001). "A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P". Proc Natl Acad Sci U S A. 98 (15): 8844–9. Bibcode:2001PNAS...98.8844S. doi:10.1073/pnas.151231598. PMC 37523. PMID 11438699.
  6. "Entrez Gene: CYFIP1 cytoplasmic FMR1 interacting protein 1".
  7. Chen Z, Borek D, Padrick SB, Gomez TS, Metlagel Z, Ismail AM, Umetani J, Billadeau DD, Otwinowski Z, Rosen MK (25 Nov 2010). "Structure and control of the actin regulatory WAVE complex". Nature. 468 (7323): 533–8. Bibcode:2010Natur.468..533C. doi:10.1038/nature09623. PMC 3085272. PMID 21107423.
  8. Koronakis V, Hume PJ, Humphreys D, Liu T, Hørning O, Jensen ON, McGhie EJ (30 Aug 2011). "WAVE regulatory complex activation by cooperating GTPases Arf and Rac1". Proc Natl Acad Sci U S A. 108 (35): 14449–54. Bibcode:2011PNAS..10814449K. doi:10.1073/pnas.1107666108. PMC 3167530. PMID 21844371.

Further reading


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