CLDN2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCLDN2, claudin 2, OAZON
External IDsOMIM: 300520 MGI: 1276110 HomoloGene: 9621 GeneCards: CLDN2
Orthologs
SpeciesHumanMouse
Entrez

9075

12738

Ensembl

ENSG00000165376

ENSMUSG00000047230

UniProt

P57739

O88552

RefSeq (mRNA)

NM_020384
NM_001171092
NM_001171095

NM_016675

RefSeq (protein)

NP_001164563
NP_001164566
NP_065117

NP_057884

Location (UCSC)Chr X: 106.9 – 106.93 MbChr X: 138.7 – 138.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Claudin-2 is a protein that in humans is encoded by the CLDN2 gene.[5][6] It belongs to the group of claudins.

Members of the claudin protein family, such as CLDN2, are expressed in an organ-specific manner and regulate the tissue-specific physiologic properties of tight junctions (Sakaguchi et al., 2002).[supplied by OMIM][6]

Function

Claudin-2 is expressed in cation-leaky epithelia such as that of the kidney proximal tubule.[7] Mice that are deficient in claudin-2 have reduced reabsorption of Na+ in the proximal tubule, consistent with a role in paracellular transport. Similar results have been obtained with cultured cells, as overexpression in claudin-2 lacking cells leads to increase of permeability for small cations.[8] Furthermore, claudin-2 has been shown to form paracellular channels for water.[9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000165376 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047230 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Morita K, Furuse M, Fujimoto K, Tsukita S (March 1999). "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands". Proc Natl Acad Sci U S A. 96 (2): 511–6. Bibcode:1999PNAS...96..511M. doi:10.1073/pnas.96.2.511. PMC 15167. PMID 9892664.
  6. 1 2 "Entrez Gene: CLDN2 claudin 2".
  7. Muto S, Hata M, Taniguchi J, Tsuruoka S, Moriwaki K, Saitou M, Furuse K, Sasaki H, Fujimura A, Imai M, Kusano E, Tsukita S, Furuse M (2010). "Claudin-2-deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules". Proceedings of the National Academy of Sciences. 107 (17): 8011–8016. Bibcode:2010PNAS..107.8011M. doi:10.1073/pnas.0912901107. PMC 2867900. PMID 20385797.
  8. Amasheh S, Meiri N, Gitter AH, Schöneberg T, Mankertz J, Schulzke JD, Fromm M (2002). "Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells". Journal of Cell Science. 115 (Pt 24): 4969–76. doi:10.1242/jcs.00165. PMID 12432083. S2CID 30696935.
  9. Rosenthal R, Milatz S, Krug SM, Oelrich B, Schulzke J-, Amasheh S, Gunzel D, Fromm M (2010). "Claudin-2, a component of the tight junction, forms a paracellular water channel". Journal of Cell Science. 123 (11): 1913–1921. doi:10.1242/jcs.060665. PMID 20460438. S2CID 19797060.

Further reading


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