Coiled-Coil Domain Containing 11, also known as CCDC11 is a protein, that is encoded by CCDC11 gene located at chromosome 18 in humans.[1]

Overview

The CCDC11 gene is located on chromosome 18q21.1 and is made of 39303 BP.[2] The CCDC11 protein is made of 514 amino acids and has a mass of 61835 Da.[2] Its aliases include coiled-coil domain containing protein 11, FLJ32743, OTTHUMP00000163503.[2]

Homology

CCDC has orthologs all the way back to betaproteobacteria which is a class of Proteobacteria.[2] The following table represents a small selection of orthologs found using searches in BLAST and BLAT. This is by no means a comprehensive list; however, it shows the diversity of species that CCDC11 is found.

Species Organism Common Name NCBI Accession Length (AAs) Sequence Identity Sequence Similarity
Homo sapiensHumanNP_659457514100%100%
Pan troglodytesChimpanzeeXP_523923.351499%99%
Callithrix jacchusMarmosetXP_002757278.151492%95%
Ailuropoda melanoleucaPandaXP_002939158.151483%91%
Canis familiarisDogXP_547689.351482%91%
Bos taurusCowXP_002697813.151481%91%
Loxodonata africanaElephantXP_003406348.151480%91%
Rattus norvegicusRatXP_001053914.251471%87%
Mus musculusMouseNP_083224.251470%87%
Ornithorhynchus anatinusPlatypusXP_001509001.246549%72%
Monodelphis domesticaOpossumXP_001372850.250747%70%
Xenopus tropicalisFrogNP_001120281.151639%65%
Anolis carolinensisLizardXP_003227331.151437%62%
Nematostella vectensisSea anemoneXP_001628275.144036%58%
Branchiostoma floridaeLanceletXP_002609924.152835%61%
Trichoplax adhaerensTrichoplaxXP_002111027.151433%60%
Danio rerioZebra fishNP_001038595.251932%58%
Amphimedon queenslandicaSpongeXP_003389146.151331%60%

Gene neighborhood

The below image from NCBI shows the gene neighborhood of CCDC11 on chromosome 18. CCDC11 has methyl-CPG binding domain protein 1, MBD1, upstream and myosin VB3, MYO5B, downstream. All CCDC11, MBD1 and MYO5B are oriented negatively. Note the close proximity between MBD1 and CCDC11.

Predicted Post-Translational Modification

Tools on the ExPASy Proteomics site[3] predict the following post-translational modifications:

Tool Predicted Modification Homo sapiens Mus musculus Bos taurus
YinOYang[4]O-β-GlcNAcT239, S510T239T239, S509, T510
NetPhos[5]phosphorylationT8, T17, S43, S53, S56, S57, Y112, T134, S170, S240, S425, S461T17, S43, S53, S56, S107, Y112, S114, S170, T284, S287, S492T17, S56, T64, S107, T112, T122, T325, S442, S482, S507

One tool on the ExPASy, iPSORT, showed no signal peptide;however, it indicated CCDC11 to be mitochondrial. Another tool on the ExPASy, SOSUI, indicated the protein to be a soluble protein.

References

  1. "coiled-coil domain containing 11". Retrieved 25 Feb 2012.
  2. 1 2 3 4 "GeneCards". Retrieved 25 Feb 2012.
  3. "ExPASy Proteomics tools". Archived from the original on 10 August 2011. Retrieved 15 Apr 2012.
  4. "YinOYang". Retrieved 15 Apr 2012.
  5. "NetPhos". Retrieved 15 Apr 2012.
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