BCAS3
Identifiers
AliasesBCAS3, GAOB1, MAAB, breast carcinoma amplified sequence 3, microtubule associated cell migration factor, BCAS3 microtubule associated cell migration factor, PHAF2, HEMARS
External IDsOMIM: 607470 MGI: 2385848 HomoloGene: 9778 GeneCards: BCAS3
Orthologs
SpeciesHumanMouse
Entrez

54828

192197

Ensembl

ENSG00000141376

ENSMUSG00000059439

UniProt

Q9H6U6

Q8CCN5

RefSeq (mRNA)

NM_001166642
NM_001166643
NM_138681

RefSeq (protein)

NP_001160114
NP_001160115
NP_619622

Location (UCSC)Chr 17: 60.68 – 61.39 MbChr 11: 85.35 – 85.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Breast carcinoma amplified sequence 3, also known as BCAS3, is a protein which in humans is encoded by the BCAS3 gene.[5][6] BCAS3 is a gene that is amplified and overexpressed in breast cancer cells.[6]

Function

The BCAS3 gene is regulated by estrogen receptor alpha (ER-α).[7] The PELP1 protein acts as a transcriptional coactivator of estrogen receptor induced BCAS3 gene expression. In addition BCAS3 possesses histone acetyltransferase activity and itself appears to act as a coactivator of ER-α.[8] Furthermore, BCAS3 requires PELP1 to function as a coactivator in ER-α. Hence BCAS3 apparently is involved in a positive feedback loop leading to ER-α mediated signal amplification.[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000141376 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000059439 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: BCAS3 breast carcinoma amplified sequence 3".
  6. 1 2 Bärlund M, Monni O, Weaver JD, Kauraniemi P, Sauter G, Heiskanen M, Kallioniemi OP, Kallioniemi A (December 2002). "Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer". Genes Chromosomes Cancer. 35 (4): 311–7. doi:10.1002/gcc.10121. PMID 12378525. S2CID 9759638.
  7. Gururaj AE, Singh RR, Rayala SK, Holm C, den Hollander P, Zhang H, Balasenthil S, Talukder AH, Landberg G, Kumar R (April 2006). "MTA1, a transcriptional activator of breast cancer amplified sequence 3". Proc. Natl. Acad. Sci. U.S.A. 103 (17): 6670–5. Bibcode:2006PNAS..103.6670G. doi:10.1073/pnas.0601989103. PMC 1458939. PMID 16617102.
  8. 1 2 Gururaj AE, Peng S, Vadlamudi RK, Kumar R (August 2007). "Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1)". Mol. Endocrinol. 21 (8): 1847–60. doi:10.1210/me.2006-0514. PMID 17505058.

Further reading


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