AKAP8
Identifiers
AliasesAKAP8, AKAP 95, AKAP-8, AKAP-95, AKAP95, A-kinase anchoring protein 8
External IDsOMIM: 604692 MGI: 1928488 HomoloGene: 4278 GeneCards: AKAP8
Orthologs
SpeciesHumanMouse
Entrez

10270

56399

Ensembl

ENSG00000105127

ENSMUSG00000024045

UniProt

O43823

Q9DBR0

RefSeq (mRNA)

NM_005858

NM_019774
NM_001357760

RefSeq (protein)

NP_005849

NP_062748
NP_001344689

Location (UCSC)Chr 19: 15.35 – 15.38 MbChr 17: 32.52 – 32.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

A-kinase anchor protein 8 is an enzyme that, in humans, is encoded by the AKAP8 gene.[5][6]

Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining it to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is located in the nucleus during interphase and is redistributed to distinct locations during mitosis. This protein has a cell cycle-dependent interaction with the RII subunit of PKA.[6]

Interactions

AKAP8 has been demonstrated to interact with:

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000105127 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024045 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 Eide T, Coghlan V, Orstavik S, Holsve C, Solberg R, Skalhegg BS, Lamb NJ, Langeberg L, Fernandez A, Scott JD, Jahnsen T, Tasken K (Mar 1998). "Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95". Exp Cell Res. 238 (2): 305–16. doi:10.1006/excr.1997.3855. PMID 9473338.
  6. 1 2 "Entrez Gene: AKAP8 A kinase (PRKA) anchor protein 8".
  7. Arsenijevic T, Degraef C, Dumont JE, Roger PP, Pirson I (Mar 2004). "A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95". Biochem. J. 378 (Pt 2): 673–9. doi:10.1042/BJ20031765. PMC 1223988. PMID 14641107.
  8. Akileswaran L, Taraska JW, Sayer JA, Gettemy JM, Coghlan VM (May 2001). "A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase". J. Biol. Chem. 276 (20): 17448–54. doi:10.1074/jbc.M101171200. PMID 11279182.
  9. Eide T, Taskén KA, Carlson C, Williams G, Jahnsen T, Taskén K, Collas P (Jul 2003). "Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication". J. Biol. Chem. 278 (29): 26750–6. doi:10.1074/jbc.M300765200. PMID 12740381.
  10. Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (Dec 2002). "AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex". J. Biol. Chem. 277 (52): 50885–92. doi:10.1074/jbc.M206387200. PMID 12414807.
  11. Collas P, Le Guellec K, Taskén K (Dec 1999). "The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis". J. Cell Biol. 147 (6): 1167–80. doi:10.1083/jcb.147.6.1167. PMC 2168084. PMID 10601332.

Further reading


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