SEC61A1
Identifiers
AliasesSEC61A1, HSEC61, SEC61, SEC61A, Sec61 alpha 1, Sec61 translocon alpha 1 subunit, HNFJ4, SEC61 translocon subunit alpha 1, ADTKD5
External IDsOMIM: 609213 MGI: 1858417 HomoloGene: 55537 GeneCards: SEC61A1
Orthologs
SpeciesHumanMouse
Entrez

29927

53421

Ensembl

ENSG00000058262

ENSMUSG00000030082

UniProt

P61619

P61620

RefSeq (mRNA)

NM_013336
NM_001400328
NM_001400329

NM_016906

RefSeq (protein)

NP_037468

NP_058602

Location (UCSC)Chr 3: 128.05 – 128.07 MbChr 6: 88.48 – 88.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein transport protein Sec61 subunit alpha isoform 1 is a protein that in humans is encoded by the SEC61A1 gene.[5]

The protein encoded by this gene belongs to the SecY/Sec61α family. It plays a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000058262 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030082 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)".

Further reading


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