phosphogluconate dehydratase
6-Phosphogluconate dehydratase monomer, Shewanella oneidensis
Identifiers
EC no.4.2.1.12
CAS no.9024-33-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
2-keto-3-deoxy-6-phosphogluconate, a product of the reaction catalysed by phosphogluconate dehydratase

The enzyme phosphogluconate dehydratase (EC 4.2.1.12) catalyzes the chemical reaction

6-phospho-D-gluconate 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming). Other names in common use include 6-phosphogluconate dehydratase, 6-phosphogluconic dehydrase, gluconate-6-phosphate dehydratase, gluconate 6-phosphate dehydratase, 6-phosphogluconate dehydrase, and 6-phospho-Dgluconate hydro-lyase. This enzyme participates in the Entner–Doudoroff pathway.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2GP4.

References

    • MELOCHE HP, WOOD WA (1964). "The Mechanism of 6-Phosphogluconic Dehydrase". J. Biol. Chem. 239: 3505–10. PMID 14245409.


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