MRPL41
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPL41, BMRP, MRP-L27, MRPL27, RPML27, PIG3, Mitochondrial ribosomal protein L41
External IDsOMIM: 611846 MGI: 1333816 HomoloGene: 13036 GeneCards: MRPL41
Orthologs
SpeciesHumanMouse
Entrez

64975

107733

Ensembl

ENSG00000182154

ENSMUSG00000036850

UniProt

Q8IXM3

Q9CQN7

RefSeq (mRNA)

NM_032477

NM_001031808

RefSeq (protein)

NP_115866

NP_001026978

Location (UCSC)Chr 9: 137.55 – 137.55 MbChr 2: 24.86 – 24.87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

39S ribosomal protein L41, mitochondrial is a protein that in humans is encoded by the MRPL41 gene.[5][6]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000182154 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036850 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (Sep 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
  6. 1 2 "Entrez Gene: MRPL41 mitochondrial ribosomal protein L41".

Further reading


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