KCNQ3
Identifiers
AliasesKCNQ3, BFNC2, EBN2, KV7.3, potassium voltage-gated channel subfamily Q member 3
External IDsOMIM: 602232 MGI: 1336181 HomoloGene: 20949 GeneCards: KCNQ3
Orthologs
SpeciesHumanMouse
Entrez

3786

110862

Ensembl

ENSG00000184156

ENSMUSG00000056258

UniProt

O43525

Q8K3F6

RefSeq (mRNA)

NM_001204824
NM_004519

NM_152923

RefSeq (protein)

NP_001191753
NP_004510

NP_690887

Location (UCSC)Chr 8: 132.12 – 132.48 MbChr 15: 65.86 – 66.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kv7.3 (KvLQT3) is a potassium channel protein coded for by the gene KCNQ3.[5]

It is associated with benign familial neonatal epilepsy.

The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and one of two related proteins encoded by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2).[5]

Interactions

KvLQT3 has been shown to interact with KCNQ5.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000184156 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056258 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: KCNQ3 potassium voltage-gated channel, KQT-like subfamily, member 3".
  6. Yus-Nájera, E; Muñoz A; Salvador N; Jensen B S; Rasmussen H B; Defelipe J; Villarroel A (2003). "Localization of KCNQ5 in the normal and epileptic human temporal neocortex and hippocampal formation". Neuroscience. 120 (2): 353–64. doi:10.1016/S0306-4522(03)00321-X. ISSN 0306-4522. PMID 12890507. S2CID 38381189.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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