Hephaestion (356 BC–324 BC) was Alexander's celebrated friend and general.
Hephaestion or Hephaistion may also refer to:
- Hephaestion (beetle), a genus of beetles
- Hephaestion (grammarian) of Alexandria, who flourished in the age of the Antonines
- Hephestion (horse) (foaled 1807), a British Thoroughbred racehorse
- Hephaestion of Thebes, 5th century astrologer
See also
- Hephaestin, a protein involved in the metabolism and homeostasis of iron
- Hephaesteion, the Temple of Hephaestus, Athens, Greece
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