Neomycin/polymyxin B/hydrocortisone
Combination of
NeomycinAntibiotic
Polymyxin BAntibiotic
HydrocortisoneGlucocorticoid
Clinical data
Trade namesOtosporin, Cortisporin, others
AHFS/Drugs.comFDA Professional Drug Information
Routes of
administration		Ear drop
ATC code
  • None
Legal status
Legal status
Identifiers
CAS Number
KEGG

Neomycin/polymyxin B/hydrocortisone, sold under the brand Otosporin among others, is a medication used to treat otitis externa (swimmer's ear) and certain eye disorders.[2][3] It consists of the antibiotics neomycin and polymyxin B, and the steroid hydrocortisone.[3] It is used as an ear drop or eye drop.[2][3]

The most common side effects include itchiness and a skin rash.[4] Other side effects may include dizziness, hives, anaphylaxis, hearing loss, and headache.[2][4] Safety in pregnancy and breastfeeding is unclear.[5] The antibiotics work by killing specific types of bacteria while the steroids work by decreasing inflammation.[6]

The combination was approved for medical use in the United States in 1964.[3] In 2020, it was the 315th most commonly prescribed medication in the United States, with more than 900 thousand prescriptions.[7]

History

Cortisporin was developed by Glaxo Wellcome and was approved by the US Food and Drug Administration in 1975. In 1997, the rights were sold to Monarch Pharmaceuticals, a division of King Pharmaceuticals. In 2007, King sold it to JHP Pharmaceuticals. Par Pharmaceutical acquired JHP in 2014. In 2015, Endo International purchased Par.[8]

Society and culture

Economics

In 2015, the price was $100, and in 2016, it reportedly was selling for $195. A generic version is priced at $144.[8] The drug is owned by Dublin, Ireland-based Endo International.

References

  1. ↑ "Neomycin and Polymyxin B Sulfates and Hydrocortisone- neomycin sulfate, polymyxin b sulfate and hydrocortisone solution". DailyMed. 22 April 2019. Retrieved 22 June 2022.
  2. 1 2 3 British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 1164. ISBN 9780857113382.
  3. 1 2 3 4 "Neomycin, Polymyxin B, Hydrocortisone Ophthalmic Suspension - FDA prescribing information, side effects and uses". Drugs.com. Retrieved 19 April 2019.
  4. 1 2 "Hydrocortisone/neomycin/polymyxin b otic Side Effects in Detail". Drugs.com. Retrieved 19 April 2019.
  5. ↑ "Hydrocortisone / neomycin / polymyxin b otic Use During Pregnancy". Drugs.com. Retrieved 19 April 2019.
  6. ↑ "DailyMed - neomycin sulfate, polymyxin b sulfate and hydrocortisone solution". dailymed.nlm.nih.gov. Retrieved 19 April 2019.
  7. ↑ "Neomycin; Polymyxin B; Hydrocortisone - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.
  8. 1 2 David L (4 February 2016). "Martin Shkreli isn't alone in ripping off patients with crazy drug prices". Los Angeles Times. Retrieved 5 February 2016.
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