Bruni is an Italian surname. Notable people with the surname include:

• Amalia Bruni, Italian politician
• Amedeo Bruni (1906-1991), Italian sports shooter
• Antonio Bruni (poet) (1593–1635), Italian poet
• Antonio Bruni (merchant) (died 1598), Albanian merchant
• Antoine Bruni d'Entrecasteaux (1737-1793), French naval officer, explorer and colonial governor
• Antonio Bartolomeo Bruni (1757–1821), Italian violist, composer and conductor
• Arturo Bruni, known professionally as Side Baby (born 1994), Italian rapper
• Bruno Bruni (artist) (born 1935), Italian artist
• Bruno Bruni (athlete) (born 1955), Italian high jumper
• Carla Bruni (born 1967), Italian-French model, singer and third wife of Nicolas Sarkozy, former President of France
• Celestino Bruni O.S.A. (XVII century), Bishop of Boiano
• Dino Bruni (born 1932), Italian road cyclist
• Domenico Bruni (1600-1666), Italian painter of the Baroque period, mainly active in Brescia
• Emily Bruni (born 1975), English actress
• Ferruccio Bruni (1899-1971), Italian middle-distance runner
• Fyodor Bruni (1799–1875), Russian painter of Italian origin
• Francesco Bruni (disambiguation), several people
• Frank Bruni (born 1964), American journalist and long-time writer for The New York Times
• Gabriele Bruni (born 1974), Italian sailor
• Georgina Bruni (1947–2008), British ufologist
• Geronimo Bruni (XVII century), Italian painter, pupil of Jacques Courtois
• Gian Giacomo Bruni (died 1507), Bishop of Nepi e Sutri
• Gianmaria Bruni (born 1981), Italian racing driver
• Giovanni Bruni (1500-1531), Albanian Bishop of Bar from Ulcinj
• Giovanni Bruni, designer of the Bruni 3V-1 Eolo glider
• Gustavo Maria Bruni (1903-1911), Italian boy under canonization by the Roman Catholic Church
• Jorge Bruni (1941–2020), Uruguayan politician
• Leonardo Bruni (c. 1370–1444), humanist, historian and chancellor of Florence
• Loïc Bruni (born 1994), professional downhill mountain biker
• Louis H. Bruni (1949-2023), Texas politician
• Ludovic Bruni (born 1976), French guitarist, bassist and music producer
• Massimo Bruni Corvino (d. 1522), Roman Catholic Bishop of Isernia
• Matteo Bruni (born 1976), Italian-British media professional
• Orazio Bruni (born c. 1630), Italian engraver
• Paolo Emilio Bruni (died 1506), Bishop of Nepi e Sutri (1507–1516)
• Rachele Bruni (born 1990), Italian swimmer
• Romulo Bruni (1871-1939), Italian cyclist
• Roberta Bruni (born 1964), Italian pole vaulter
• Rodrigo Bruni (born 1993), Argentine rugby union player of the national Argentina team
• Sergio Bruni (1921-2003), Italian singer, guitarist, and songwriter
• Teofilo Bruni (1569-1638), Italian mathematician and astronomer
• Umberto Bruni (1914–2021), Canadian artist and painter
• Valeria Bruni Tedeschi (born 1964), Italian-French actress and sister of Carla Bruni
• Virgile Bruni (born 1989), French rugby union player

Others

• Bruni Löbel (1920-2006), German stage, film and television actress