| S-Adenosylhomocysteine hydrolase | |||||||
|---|---|---|---|---|---|---|---|
 SAH hydrolase tetramer, Human | |||||||
| Identifiers | |||||||
| Symbol | AHCY | ||||||
| NCBI gene | 191 | ||||||
| HGNC | 343 | ||||||
| OMIM | 180960 | ||||||
| RefSeq | NM_000687 | ||||||
| UniProt | P23526 | ||||||
| Other data | |||||||
| EC number | 3.3.1.1 | ||||||
| Locus | Chr. 20 q11.22 | ||||||
| |||||||
Adenosylhomocysteinase (EC 3.3.1.1, S-adenosylhomocysteine synthase, S-adenosylhomocysteine hydrolase, adenosylhomocysteine hydrolase, S-adenosylhomocysteinase, SAHase, AdoHcyase) is an enzyme that converts S-adenosylhomocysteine to homocysteine and adenosine.[1][2] This enzyme catalyses the following chemical reaction
- S-adenosyl-L-homocysteine + H2O ⇌ L-homocysteine + adenosine
The enzyme contains one tightly bound NAD+ per subunit. The mechanism involves dehydrogenative oxidation of the 3'-OH of the ribose. The resulting ketone is susceptible to α-deprotonation. The resulting carbanion eliminates thiolate. The a,b-unsaturated ketone is then hydrated, and the ketone is reduced by the NADH.
This enzyme is encoded by the AHCY gene in humans,[3][4] which is believed to have a prognostic role in neuroblastoma.[5]
References
- ↑ De La Haba G, Cantoni GL (March 1959). "The enzymatic synthesis of S-adenosyl-L-homocysteine from adenosine and homocysteine". The Journal of Biological Chemistry. 234 (3): 603–8. doi:10.1016/S0021-9258(18)70253-6. PMID 13641268.
- ↑ Palmer JL, Abeles RH (February 1979). "The mechanism of action of S-adenosylhomocysteinase". The Journal of Biological Chemistry. 254 (4): 1217–26. doi:10.1016/S0021-9258(17)34190-X. PMID 762125.
- ↑ GeneCards.org - AHCY Gene - Adenosylhomocysteinase
- ↑ NLM - AHCY adenosylhomocysteinase
External links
- Adenosylhomocysteinase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Further reading
- Vizán, Pedro; Di Croce, Luciano; Aranda, Sergi (31 March 2021). "Functional and Pathological Roles of AHCY". Frontiers in Cell and Developmental Biology. 9. doi:10.3389/fcell.2021.654344. eISSN 2296-634X. PMC 8044520. PMID 33869213.
- Vugrek, Oliver; Belužić, Robert; Nakić, Nikolina; Mudd, S. Harvey (28 January 2009). "S-adenosylhomocysteine hydrolase (AHCY) deficiency: Two novel mutations with lethal outcome". Human Mutation. 30 (4): E555–E565. doi:10.1002/humu.20985. ISSN 1059-7794. PMC 2876820. PMID 19177456.
- Chicco, Davide; Sanavia, Tiziana; Jurman, Giuseppe (4 March 2023). "Signature literature review reveals AHCY, DPYSL3, and NME1 as the most recurrent prognostic genes for neuroblastoma". BioData Mining. 16 (1): 7. doi:10.1186/s13040-023-00325-1. eISSN 1756-0381. PMC 9985261. PMID 36870971.